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MYP_066997
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Basic Information
SC18EK
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Standard
18 amino acids
C111H166N24O35
Standard
Sequence
WEEWDKKIEEYTKKIEEL
Physicochemical Analysis
2396.65 Da
4.55
-3.23
-3.45
-0.1793
-1.73
0.64
-0.32
85.38
65.00
0.1667
12490.00
12490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
995.24
-3.27
34.0
32.0
84.0
170.0
5.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0014271 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 NL4-3:inhibition of pseudovirus entry in TZM-bl cells
2 μM
IC50
PaperConserved Residue Asn-145 in the C-Terminal Heptad Repeat Region of HIV-1 gp41 is Critical for Viral Fusion and Regulates the Antiviral Activity of Fusion Inhibitors. Viruses. 2019 Jul 3;11(7):609. doi: 10.3390/v11070609. PMID: 31277353. PMID31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31277353/
RECORD: Rec_0064319 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 NL4-3 | TZM-bl cells
2 μM
IC50
Mammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min
PaperConserved Residue Asn-145 in the C-Terminal Heptad Repeat Region of HIV-1 gp41 is Critical for Viral Fusion and Regulates the Antiviral Activity of Fusion Inhibitors. | Geng X, Liu Z, Yu D, Qin B, Zhu Y, Cui S, Chong H, He Y. | Viruses. 2019 Jul 3;11(7):609. | DOI:10.3390/v11070609 | PMID:31277353 PMID31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31277353/
RECORD: Rec_0135891 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 NL4-3 PsV
PMID31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31277353/
RECORD: Rec_0166190 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 HxB2
PMID31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31277353/
RECORD: Rec_0201185 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 HXB2:inhibition of cell-cell fusion in TZM-bl cells
2 μM
IC50
PaperConserved Residue Asn-145 in the C-Terminal Heptad Repeat Region of HIV-1 gp41 is Critical for Viral Fusion and Regulates the Antiviral Activity of Fusion Inhibitors. Viruses. 2019 Jul 3;11(7):609. doi: 10.3390/v11070609. PMID: 31277353. PMID31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31277353/
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