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MYP_066959
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Basic Information
MagaininF5W-Lys
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
23 amino acids
C116H181N31O29S
Standard
Sequence
GIGKWLHSAKKFGKAFVGEIMNS
Physicochemical Analysis
2505.93 Da
10.00
2.85
2.59
0.1237
-0.08
0.66
0.16
5.26
72.17
0.1304
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
972.92
-7.41
34.0
34.0
86.0
177.0
5.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0254366 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Magainin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli ATCC 25922
20 μM
MIC
PMID32786298 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32786298/
RECORD: Rec_0265684 VERIFIED: YES
Provenance & Taxonomy
porcine cathelicidin peptide [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Jurkat
16.8 μM
IC50
PaperSelective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin. Biochim Biophys Acta Biomembr. 2020 Aug 1;1862(8):183228. doi: 10.1016/j.bbamem.2020.183228. PMID: 32126228. PMID32126228 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32126228/
RECORD: Rec_0303816 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Magainin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Cytotoxic
Human PBMC
>=65
IC50
PMID32786298 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32786298/
RECORD: Rec_0362946 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
Magainin
8355
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiparasitic Antileishmanial
Leishmania donovani MHOM/SD/00/1S-2D (promastigote)
8.3 μM
LD50; MTT assay
PMID15273109 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15273109/
RECORD: Rec_0400312 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Magainin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus epidermidis ATCC 12228
40 μM
MIC
PMID32786298 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32786298/
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