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MYP_066901
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Basic Information
peptide 5
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition
Standard
26 amino acids
C152H266N60O31
Standard
Sequence
EAIIRILQQLLFIHFRIGRRRRRRRR
Physicochemical Analysis
3430.12 Da
12.00
8.92
8.70
0.3432
-0.68
0.73
-0.56
191.94
123.85
0.0769
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1561.98
-11.98
61.0
41.0
122.0
243.0
3.0
27.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0248836 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
inhibition of strand transfer catalyzed by integrase
0.04±0.01 μM
IC50
PaperPeptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies PMID20708407 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20708407/
RECORD: Rec_0266223 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
inhibition of strand transfer catalyzed by integrase
0.006±0.006 μM
IC50
PMID20586421 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20586421/
RECORD: Rec_0270101 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-HIV-1 Integrase inhibition
HIV-1
0.09±0.01 μM
IC50
Mammalian: 1 h; Yeast: 30 min; E. coli: >10 h
PaperPeptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies. | Suzuki S, Maddali K, Hashimoto C, Urano E, Ohashi N, Tanaka T, Ozaki T, Arai H, Tsutsumi H, Narumi T, Nomura W, Yamamoto N, Pommier Y, Komano JA, Tamamura H. | Bioorg Med Chem. 2010 Sep 15;18(18):6771-5. | DOI:10.1016/j.bmc.2010.07.050 | PMID:20708407 PMID20708407 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20708407/
RECORD: Rec_0306319 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Replication inhibition
inhibition of strand transfer catalyzed by integrase
0.006±0.006 μM
IC50
Mammalian: 1 h; Yeast: 30 min; E. coli: >10 h
PaperPeptide HIV-1 integrase inhibitors from HIV-1 gene products. | Suzuki S, Urano E, Hashimoto C, Tsutsumi H, Nakahara T, Tanaka T, Nakanishi Y, Maddali K, Han Y, Hamatake M, Miyauchi K, Pommier Y, Beutler JA, Sugiura W, Fuji H, Hoshino T, Itotani K, Nomura W, Narumi T, Yamamoto N, Komano JA, Tamamura H. | J Med Chem. 2010 Jul 22;53(14):5356-60. | DOI:10.1021/jm1003528 | PMID:20586421 PMID20586421 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20586421/
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