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MYP_066830
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Basic Information
P12
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Reverse transcriptase inhibition
Standard
17 amino acids
C74H124N18O29S
Standard
Sequence
GTKALTEVIPATEEAEC
Physicochemical Analysis
1761.94 Da
4.09
-3.24
-3.47
-0.1906
-0.09
0.45
0.10
81.74
80.59
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
756.04
-8.24
26.0
27.0
57.0
122.0
1.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0173985 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:inhibition of polymerase activity of HIV-1 RT(Ki =22 ± 3 μM)
PaperA New Generation of Peptide-based Inhibitors Targeting HIV-1 Reverse Transcriptase Conformational Flexibility PMID18952602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18952602/
RECORD: Rec_0175173 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperA New Generation of Peptide-based Inhibitors Targeting HIV-1 Reverse Transcriptase Conformational Flexibility PMID18952602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18952602/
RECORD: Rec_0230966 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Replication inhibition
HIV-1
22±3 μM
KI
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperA new generation of peptide-based inhibitors targeting HIV-1 reverse transcriptase conformational flexibility. | Agopian A, Gros E, Aldrian-Herrada G, Bosquet N, Clayette P, Divita G. | J Biol Chem. 2009 Jan 2;284(1):254-264. | DOI:10.1074/jbc.M802199200 | PMID:18952602 PMID18952602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18952602/
RECORD: Rec_0237931 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 58.8%, C 41.2% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperHIPdb: a database of experimentally validated HIV inhibiting peptides PMID23359817 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23359817/
RECORD: Rec_0412717 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Reverse transcriptase inhibition
HeLa
22±3 μM
Ki
PaperA new generation of peptide-based inhibitors targeting HIV-1 reverse transcriptase conformational flexibility. PMID18952602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18952602/