Peptide Database

Peptide NameSC25EK

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length25 amino acids

Chemical FormulaC147H228N34O48

DescriptionStandard

        WEEWDKKIEEYTKKIEELIKKSEEQ
    

Molecular Weight3239.58 Da

Isoelectric Point (pI)4.73

Net Charge (pH 7.0)-3.22

Net Charge (pH 7.4) -3.45

Charge Density (pH 7.0) -0.1289

GRAVY Index-1.83

Hydrophobic Moment 0.69

Boman Index-0.39

Instability Index89.33

Aliphatic Index 62.40

Aromaticity 0.1200

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1388.90

LogP -7.58

H-bond Donors 47.0

H-bond Acceptors 45.0

Rotatable Bonds 118.0

Heavy Atoms 229.0

Ring Count 5.0

Amide Bonds 25.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0194003 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyFusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Fusion inhibition

TargetHIV-1 HXB2 | TZM-bl cells

Activity0.0415±0.0031 μM

MethodIC50

Half-LifeMammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min

PaperConserved Residue Asn-145 in the C-Terminal Heptad Repeat Region of HIV-1 gp41 is Critical for Viral Fusion and Regulates the Antiviral Activity of Fusion Inhibitors. | Geng X, Liu Z, Yu D, Qin B, Zhu Y, Cui S, Chong H, He Y. | Viruses. 2019 Jul 3;11(7):609. | DOI:10.3390/v11070609 | PMID:31277353 PMID31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31277353/

RECORD: Rec_0238451 VERIFIED: YES