Peptide Database

Peptide NameColicin-E3 (EC 3.1.-.-)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Enzyme / Catalytic activity ▸ Hydrolase

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length511 amino acids

Chemical FormulaC2443H3800N698O747S18

DescriptionStandard

        MASVNRGCTVHGQNVGLHGDKTSTGSQCIAARPGMSVMGKWKLYIGDITTPCPKCGKVGVIVTGDHRQTNVEAVAVDGSIIHCDCPSGSNFLIAPGTVEINDPFGMLEPAVNKTIATATAPSVLPVYAKSCLRGEGCTDAGTEQELLDNFGHASYYRAASQKEQSKQEPVQHAQAAKKHKPAEPTPPPEDNRPWYKRLFSSPDTTKAAAAAGMATARAATTTGITTGATTEAGYAALQQIGGTLSTAGRWIAPSPPTVLLFGMFYSPKLNSGEQDYIDKMRLEQAAQNKEDVPTRVRFRWEADQNGMIRPKGFHVSARGGQDKVPVRMLQKNTTTGNYEFWEDGASKPTIVWIPDDPGYVSPSNTGNRDNVYVPPSVLVYPESEINSPWSTETPAPGERPFRDYILVHPAGTFDPIYIYLNAAHKYHVAPRGTPPLPAFPDAKTAKKRTPVKGGGTLRSRWKDSKGRIFEWDSQHGTVEMYDRSGRNHLGEFDPVSGEQTKPADPTRRVEK
    

Molecular Weight55477.71 Da

Isoelectric Point (pI)8.60

Net Charge (pH 7.0)5.61

Net Charge (pH 7.4) 4.49

Charge Density (pH 7.0) 0.0110

GRAVY Index-0.59

Hydrophobic Moment 0.63

Boman Index-0.04

Instability Index50.95

Aliphatic Index 60.94

Aromaticity 0.0783

Extinction Coeff. Reduced 74830.00

Extinction Coeff. Oxidized 75330.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0281802 VERIFIED: NO

Provenance & Taxonomy

OrganismKluyvera ascorbata [Bacterium]

FamilyColicin/Bacteriocin

Tax ID1006000

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Anti-Gram-negative Hydrolase Non-hemolytic

TargetEscherichia coli (Gram-negative)

MethodQualitative functional evidence