Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length196 amino acids

Chemical FormulaC992H1559N267O267S11

DescriptionStandard

        PMTHPMAHEPMLLLAVTEFVANSAAFTYFTAGALRRNISSDMLPRQFPLQLRTKSMEVFSPQLQERYPDQPMELHLWARQQPLLSCHPDALHGTLFSSAEAFVVLPNTTRVPAFLLNIDANVTGKPTITRNRLGGTVRLTGLVPDPELAWTPLPVLCWAQGLPVPQVKRLETLLKFGLWLFGVPRANSKCCPCEVP
    

Molecular Weight21850.33 Da

Isoelectric Point (pI)8.78

Net Charge (pH 7.0)3.37

Net Charge (pH 7.4) 2.96

Charge Density (pH 7.0) 0.0172

GRAVY Index0.03

Hydrophobic Moment 0.55

Boman Index0.11

Instability Index50.15

Aliphatic Index 92.55

Aromaticity 0.0816

Extinction Coeff. Reduced 24980.00

Extinction Coeff. Oxidized 25230.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 8356.32

LogP -99.41

H-bond Donors 287.0

H-bond Acceptors 286.0

Rotatable Bonds 683.0

Heavy Atoms 1537.0

Ring Count 47.0

Amide Bonds 211.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0223801 VERIFIED: NO

Provenance & Taxonomy

OrganismCerthia brachydactyla [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria