Peptide Database

Peptide Name[Ala3,Thr6]-bradykinin

Function Ontology

Antimicrobial

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length9 amino acids

Chemical FormulaC49H73N15O11

DescriptionStandard

        RPAGFTPFR
    

Molecular Weight1048.20 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)1.76

Net Charge (pH 7.4) 1.56

Charge Density (pH 7.0) 0.1956

GRAVY Index-0.66

Hydrophobic Moment 0.34

Boman Index-0.15

Instability Index73.09

Aliphatic Index 11.11

Aromaticity 0.2222

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 422.57

LogP -3.67

H-bond Donors 15.0

H-bond Acceptors 13.0

Rotatable Bonds 28.0

Heavy Atoms 75.0

Ring Count 4.0

Amide Bonds 8.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0020653 VERIFIED: YES

Provenance & Taxonomy

OrganismBombina variegata [Animal]

Familybradykinin

Tax ID8348

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Myotropic

Targetvitro relaxation of rat arterial smooth muscle

Half-LifeMammalian: 1 hour; Yeast: 2 min; E. coli: 2 min

RECORD: Rec_0111818 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide; DSSP H 0.0%, E 0.0%, T 33.3%, C 66.7% [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0210543 VERIFIED: NO

Provenance & Taxonomy

OrganismBombina variegata [Animal]

FamilyBradykinin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

RECORD: Rec_0390925 VERIFIED: YES

Provenance & Taxonomy

OrganismBombina variegata [Animal]

Family-bradykinin

Structure & Mods

Configribosomal mature linear peptide [Linear]

ChiralityGene-encoded natural peptide composed of standard L-amino acids [L]

Bio-Activity Profile

Function

Smooth muscle contraction Vasorelaxant Insulin releasing