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MYP_066501
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Basic Information
LK [L8E]
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
16 amino acids
C88H166N22O19
Standard
Sequence
LKKLLKLEKKLLKLAG
Physicochemical Analysis
1836.40 Da
10.30
4.76
4.54
0.2973
0.07
0.69
-0.08
-27.77
176.88
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
693.24
-0.72
24.0
24.0
72.0
129.0
0.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0011264 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Human erythrocytes (10% Hemolysis at 320 μM
320 μM
Hemolysis
PMID23894079 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23894079/
RECORD: Rec_0025615 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli ATCC 25922
5 μM
MIC
PMID23894079 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23894079/
RECORD: Rec_0107671 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic
human red blood cells
PaperDisruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of α-helical amphipathic peptides PMID23894079 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23894079/
RECORD: Rec_0145990 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Gram-positive bacteria: Staphylococcus aureus (ATCC 29213)
40 μM
MIC
PaperDisruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of α-helical amphipathic peptides PMID23894079 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23894079/
RECORD: Rec_0303363 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic
PaperDisruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of α-helical amphipathic peptides PMID23894079 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23894079/
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