Peptide Database

Peptide Name5-

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Influenza virus

Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC78H143N23O16

DescriptionStandard

        RRKKLPAVLLALLAP
    

Molecular Weight1659.11 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)3.76

Net Charge (pH 7.4) 3.55

Charge Density (pH 7.0) 0.2505

GRAVY Index0.57

Hydrophobic Moment 0.35

Boman Index0.03

Instability Index80.38

Aliphatic Index 169.33

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 628.98

LogP -2.07

H-bond Donors 22.0

H-bond Acceptors 20.0

Rotatable Bonds 54.0

Heavy Atoms 117.0

Ring Count 2.0

Amide Bonds 14.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0412475 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-Influenza virus Replication inhibition

TargetInfluenza virus | MDCK cells

Activity10 μM

Method% inhibition

Half-LifeMammalian: 1 h; Yeast: 2 min; E. coli: 2 min

PaperIdentification of the minimal active sequence of an anti-influenza virus peptide. | Jones JC, Settles EW, Brandt CR, Schultz-Cherry S. | Antimicrob Agents Chemother. 2011 Apr;55(4):1810-3. | DOI:10.1128/AAC.01428-10 | PMID:21220525 PMID21220525 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21220525/

FIRST PREV 1 2

Showing 1 records on this page Ã‚Â· Page 2 of 2