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MYP_066457
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Basic Information
Hepcidin
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Antifungal
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Regulatory peptide ▸ Biological modulation
Standard
25 amino acids
C113H178N34O31S9
Standard
Sequence
DTHFPICIFCCGCCHRSKCGMCCKT
Physicochemical Analysis
2797.42 Da
8.22
1.85
1.43
0.0742
0.39
0.15
0.07
37.76
31.20
0.0800
0.00
500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1022.22
-11.75
44.0
44.0
88.0
187.0
5.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0355055 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
hepcidin family
9606; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
7-23; 10-13; 11-19; 14-22
Bio-Activity Profile
Antimicrobial hepcidin family Antibacterial Antifungal Hormone Host defense
PaperPDB 4QAE structural record; X-ray; 2.10 A; chain P/Q/R/S/T/U; residues 1-25
RECORD: Rec_0372564 VERIFIED: NO
Provenance & Taxonomy
Hylobates lar [Animal]
Hepcidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperHepcidin Evidence URLhttps://www.uniprot.org/uniprotkb/A7XEI9/entry
RECORD: Rec_0390890 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Hepcidin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Bacillus subtilis
40000 μg/mL
MIC
PMID11034317;11113131 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11034317/
RECORD: Rec_0393190 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Hepcidin
9606
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
7-23; 10-13; 11-19; 14-22
Bio-Activity Profile
Antimicrobial Hormone Endocrine Receptor modulation Immunomodulatory ACE inhibitory
Mammalian: 1.1 hour; Yeast: 3 min; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Hepcidin-25 (Homo sapiens): PMID 11113131##22306005 PMID11113131;22306005 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11113131/
RECORD: Rec_0415461 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Hepcidin
9606
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli
PaperPubMed PMID: 11034317 | PubMed PMID: 11113131 | PubMed PMID: 12138110 | PubMed PMID: 19553669 PMID11034317;11113131;12138110;19553669 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11034317/
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