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MYP_066457
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Basic Information
Hepcidin
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Antifungal
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Regulatory peptide ▸ Biological modulation
Standard
25 amino acids
C113H178N34O31S9
Standard
Sequence
DTHFPICIFCCGCCHRSKCGMCCKT
Physicochemical Analysis
2797.42 Da
8.22
1.85
1.43
0.0742
0.39
0.15
0.07
37.76
31.20
0.0800
0.00
500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1022.22
-11.75
44.0
44.0
88.0
187.0
5.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0294782 VERIFIED: NO
Provenance & Taxonomy
Nomascus concolor [Animal]
Hepcidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperHepcidin Evidence URLhttps://www.uniprot.org/uniprotkb/A7XEI8/entry
RECORD: Rec_0310633 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Hepcidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0314287 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
RECORD: Rec_0331871 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Hepcidin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus epidermidis
PMID11034317;11113131 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11034317/
RECORD: Rec_0354786 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Hepcidin
9606
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans
PaperPubMed PMID: 11034317 | PubMed PMID: 11113131 | PubMed PMID: 12138110 | PubMed PMID: 19553669 PMID11034317;11113131;12138110;19553669 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11034317/
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