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MYP_066457
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Basic Information
Hepcidin
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Antifungal
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Regulatory peptide ▸ Biological modulation
Standard
25 amino acids
C113H178N34O31S9
Standard
Sequence
DTHFPICIFCCGCCHRSKCGMCCKT
Physicochemical Analysis
2797.42 Da
8.22
1.85
1.43
0.0742
0.39
0.15
0.07
37.76
31.20
0.0800
0.00
500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1022.22
-11.75
44.0
44.0
88.0
187.0
5.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0204825 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Hepcidin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antimycobacterial Immunomodulatory
Mycobacterium tuberculosis H37Rv
PMID25613372 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25613372/
RECORD: Rec_0228099 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperKrause A., Neitz S., Maegert H.J., Schulz A., Forssmann W.G., Schulz-Knappe P., Adermann K.;. LEAP-1, a novel highly disulfide-bonded human peptide exhibits antimicrobial activity."; FEBS Lett. 480:147-150. Evidence URLhttps://www.uniprot.org/uniprotkb/HEPC_HUMAN/entry
RECORD: Rec_0234043 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Hepcidin
9606
Structure & Mods
cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
None
7-23, 10-13, 11-19, 14-22
Bio-Activity Profile
Antimicrobial Antimycobacterial Anticancer Immunomodulatory
Mycobacterium H37Rv
IC50
PMID21482189 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21482189/
RECORD: Rec_0236891 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Hepcidin
9606
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
allo-residue reported
Bio-Activity Profile
Antimicrobial Antifungal
Micrococcus luteus, S. carnosus, and Gram-negative N. cinerea as well as the yeast Saccharomyces cerevisiae
50 μg/mL
IC50
Paperref1) LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. ref2) Hepcidin, a rinary antimicrobial peptide synthesized in the liver
RECORD: Rec_0247963 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Hepcidin
9606
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Aspergillus fumigatus
PaperPubMed PMID: 11034317 | PubMed PMID: 11113131 | PubMed PMID: 12138110 | PubMed PMID: 19553669 PMID11034317;11113131;12138110;19553669 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11034317/
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