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MYP_066396
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Basic Information
C14-HBD-3 (22-45) [C33,41Del], MPhd-3
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
22 amino acids
C106H194N40O31S2
Standard
Sequence
SCLPKEEQIGKSTRGRKCRRKK
Physicochemical Analysis
2589.05 Da
10.56
6.44
6.19
0.2928
-1.79
0.34
-0.74
83.76
35.45
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1221.71
-15.64
47.0
40.0
96.0
179.0
1.0
22.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0281245 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus ATCC 8530[LC = 17 microM
PMID24086767;16860904;18809937;23980689;29682907 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24086767/
RECORD: Rec_0281597 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus NCTC 8530
11 μg/mL
MBC
PMID24086767;16860904;18809937;23980689;29682907 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24086767/
RECORD: Rec_0281986 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
2-18
Bio-Activity Profile
Antimicrobial
Escherichia coli (LC 16 uM). LC=lethal concentration. Antimicrobial robustness: NaCl-insensitive:Escherichia coli (150 mM); MgCl2-sensitive:Escherichia coli (2.5 mM)
PaperHuman-beta-defensins-1-3 and analogs do not require proton motive force for antibacterial activity against Escherichia coli.
RECORD: Rec_0332985 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli MG1655[LC = 17 microM
PMID24086767;16860904;18809937;23980689;29682907 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24086767/
RECORD: Rec_0389454 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
- at NA , Rat erythrocytes
12.5 μM
Hemolysis
PMID24086767;16860904;18809937;23980689;29682907 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24086767/
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