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MYP_066290
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Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
17 amino acids
C99H154N32O20S4
Standard
Sequence
KWCFRVCYRGICYRKCR
Physicochemical Analysis
2240.74 Da
9.79
5.72
5.45
0.3363
-0.48
0.65
-0.38
-20.47
40.00
0.2353
8480.00
8730.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
884.81
-5.62
39.0
30.0
72.0
155.0
5.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0219824 VERIFIED: YES
Provenance & Taxonomy
Limulus polyphemus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Micrococcus luteus B-1314
2 μM
MIC
PMID30486233 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30486233/
RECORD: Rec_0221129 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antibacterial Antimicrobial Anti-Gram-positive Anti-Gram-negative Antibiofilm
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0229854 VERIFIED: YES
Provenance & Taxonomy
Tachypleus gigas [Animal]
Tachyplesin
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus ATCC 25923, and Staphylococcus aureus ATCC 6538
1-8 μM
MIC
PaperTachyplesins isolated from hemocytes of Southeast Asian horseshoe crabs (Carcinoscorpius rotundicauda and Tachypleus gigas): identification of a new tachyplesin, tachyplesin III, and a processing intermediate of its precursor.
RECORD: Rec_0230540 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Tachyplesin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiofilm Antibacterial
Pseudomonas aeruginosa ATCC 27853
14.291, 1.786 μM
Total countable CFUs
RECORD: Rec_0245765 VERIFIED: YES
Provenance & Taxonomy
Tachypleus gigas [Animal]
Tachyplesin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PaperJ Biochem. 1990 Aug;108(2):261-6. | http://www.ncbi.nlm.nih.gov/pubmed/2229025 PMID2229025 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2229025/
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