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MYP_066281
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Basic Information
I7R
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
8 amino acids
C68H89N21O9
Standard
Sequence
WWWLRRRW
Physicochemical Analysis
1344.57 Da
12.00
2.76
2.56
0.3450
-1.66
0.38
-0.41
263.05
48.75
0.5000
22000.00
22000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
515.88
1.52
22.0
12.0
37.0
98.0
8.0
7.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0001746 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Pleurocidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
(C terminal: NH2): Staphylococcus aureus G16
32 μg/mL
MIC
PMID33804947 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33804947/
RECORD: Rec_0031467 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Pleurocidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
human RBCs
150 μM
Hemolysis
PMID28731688;33804947 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28731688/
RECORD: Rec_0039102 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
50%; R: 38%; L:13%. Mol. Wt: 1344.591; GRAVY: -1.66; Mol. ex. coeff.: 22200
Bio-Activity Profile
Antimicrobial Antifungal
pathogens, inlcuding 32 Staphylococcus aureus clinical strains
4 μM
MIC50
Unspecified 48 h
PaperTwo distinct amphipathic peptide antibiotics with systemic efficacy. PMID32723829 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32723829/
RECORD: Rec_0065772 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Pleurocidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
(C terminal: NH2): Staphylococcus aureus G16
64 μg/mL
MIC
PMID33804947 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33804947/
RECORD: Rec_0123000 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
50%; R: 38%; L:13%. Mol. Wt: 1344.591; GRAVY: -1.66; Mol. ex. coeff.: 22200
Bio-Activity Profile
Antimicrobial Antifungal Toxicity
human kidney HEK293
>100 μM
LC50
Unspecified 48 h
PaperTwo distinct amphipathic peptide antibiotics with systemic efficacy. PMID32723829 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32723829/
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