Peptide Database

Peptide NameSLAY-screened peptide P5727

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC80H129N23O27

DescriptionStandard

        VNAANPTGISYRPPLSST
    

Molecular Weight1845.02 Da

Isoelectric Point (pI)8.72

Net Charge (pH 7.0)0.73

Net Charge (pH 7.4) 0.52

Charge Density (pH 7.0) 0.0407

GRAVY Index-0.32

Hydrophobic Moment 0.26

Boman Index0.06

Instability Index21.12

Aliphatic Index 70.56

Aromaticity 0.0556

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 801.11

LogP -11.72

H-bond Donors 27.0

H-bond Acceptors 28.0

Rotatable Bonds 52.0

Heavy Atoms 130.0

Ring Count 4.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0052421 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/