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MYP_066218
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Basic Information
Temporin-SHa
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
13 amino acids
C67H108N14O15S
Standard
Sequence
FLSGIVGMLGKLF
Physicochemical Analysis
1381.72 Da
8.75
0.76
0.55
0.0584
1.67
0.43
0.65
-23.42
142.31
0.1538
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
458.77
-0.69
16.0
17.0
46.0
97.0
2.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0129868 VERIFIED: YES
Provenance & Taxonomy
Pelophylax saharica [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 35218
10 μM
MIC
PMID18584916 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18584916/
RECORD: Rec_0144868 VERIFIED: YES
Provenance & Taxonomy
Pelophylax saharica [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
C. parapsilosis ATCC 22019
31 μM
MIC
PMID18584916 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18584916/
RECORD: Rec_0153504 VERIFIED: YES
Provenance & Taxonomy
Pelophylax saharica [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Bacillus megaterium
2 μM
MIC
PMID18584916 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18584916/
RECORD: Rec_0158840 VERIFIED: YES
Provenance & Taxonomy
Pelophylax saharicus [Animal]
Cathelicidin
70019
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-HSV Entry inhibition
HSV-1
10 μM
% inhibition
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperComparison of Anti-Viral Activity of Frog Skin Anti-Microbial Peptides Temporin-Sha and [K³]SHa to LL-37 and Temporin-Tb against Herpes Simplex Virus Type 1. | Roy M, Lebeau L, Chessa C, Damour A, Ladram A, Oury B, Boutolleau D, Bodet C, Lévêque N. | Viruses. 2019 Jan 18;11(1):77. | DOI:10.3390/v11010077 | PMID:30669255 PMID30669255 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30669255/
RECORD: Rec_0159231 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Animal]
Temporin
8407
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiparasitic Antileishmanial
Leishmania mexicana MNYC/BZ/62/M379 (promastigote)
100 μM
Alamar Blue assay
PMID21805542 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21805542/
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