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MYP_066218
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Basic Information
Temporin-SHa
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
13 amino acids
C67H108N14O15S
Standard
Sequence
FLSGIVGMLGKLF
Physicochemical Analysis
1381.72 Da
8.75
0.76
0.55
0.0584
1.67
0.43
0.65
-23.42
142.31
0.1538
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
458.77
-0.69
16.0
17.0
46.0
97.0
2.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0013788 VERIFIED: YES
Provenance & Taxonomy
Pelophylax saharica [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
C-terminal NH2
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Antiparasitic
Pseudomonas aeruginosa ATCC 27853
31 μM
MIC
PaperIsolation, characterization and molecular cloning of new temporins from the skin of the North African ranid Pelophylax saharica.
RECORD: Rec_0050184 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiparasitic Toxic Anti-Gram-positive Cytotoxic Antileishmanial Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0055415 VERIFIED: YES
Provenance & Taxonomy
Pelophylax saharica [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 25923
3 μM
MIC
PMID18584916 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18584916/
RECORD: Rec_0057517 VERIFIED: YES
Provenance & Taxonomy
Pelophylax saharicus [Animal]
Temporin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
3.0 μM
MIC
PaperF. Abbassi et al. / Peptides 29 (2008) 1526-1533. Isolation, characterization and molecular cloning of new temporins from the skin of the North African ranid Pelophylax saharica
RECORD: Rec_0059886 VERIFIED: YES
Provenance & Taxonomy
Pelophylax saharicus [Animal]
Temporin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antifungal
PaperF. Abbassi et al. / Peptides 29 (2008) 1526-1533. Isolation, characterization and molecular cloning of new temporins from the skin of the North African ranid Pelophylax saharica
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