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MYP_066145
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Basic Information
Antimicrobial peptide CHP1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
39 amino acids
C196H321N59O49S6
Standard
Sequence
GRKSDCFRKSGFCAFLKCPSLTLISGKCSRFYLCCKRIR
Physicochemical Analysis
4480.40 Da
9.90
8.70
8.40
0.2230
-0.05
0.54
-0.16
36.92
62.56
0.1282
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1778.84
-18.21
73.0
64.0
152.0
310.0
6.0
38.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0310376 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Antifungal Anti-Gram-positive Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0340581 VERIFIED: YES
Provenance & Taxonomy
Gallus gallus [Animal]
Defensin
9031
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Three disulfide bonds: 6,28; 13,34; 18,35;
Bio-Activity Profile
Antimicrobial Antifungal
Escherichia coli
16 μg/mL
MIC
PaperIsolation of antimicrobial peptides from avian heterophils.
RECORD: Rec_0404523 VERIFIED: YES
Provenance & Taxonomy
Gallus gallus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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