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MYP_066132
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Basic Information
Unnamed
Annotation / Sequence feature ▸ Nuclear export signal
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Xaa-Pro Inhibitor
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Regulatory peptide ▸ Stimulation activity
Standard
3 amino acids
C16H29N3O4
Standard
Sequence
VPL
Physicochemical Analysis
327.42 Da
5.50
-0.27
-0.48
-0.0887
2.13
0.08
0.75
70.87
226.67
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
112.73
0.58
3.0
4.0
7.0
23.0
1.0
2.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0106992 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Xaa-Pro Inhibitor
600.0
IC50
PaperRigolet P., Xi X. G., Rety S., Chich J.-F.. The structural comparison of the bacterial PepX and human DPP-IV reveals sites for the design of inhibitors of PepX activity. FEBS J., 272, 2050-2059, 2005.
RECORD: Rec_0129060 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiamnestic
47.0
PaperMaruyama S., Ohmori T., Nakagami T.. Prolyl endopeptidase inhibitory activity of a glial fibrillary acidic protein fragment and other proline-rich peptides. Biosci. Biotech. Biochem. 60(2), 358-359 (1996).
RECORD: Rec_0217989 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antidiabetic DPP-IV inhibitory
Dipeptidyl peptidase IV
15.8
IC50
PaperNongonierma A. B., FitzGerald R. J.. An in silico model to predict the potential of dietary proteins as sources of dippetidyl peptidase IV (DPP-IV) inhibitory peptides. Food Chemistry 165 (2014), 489-498.
RECORD: Rec_0361967 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Stimulatory
PaperRingseis R., Motthes B., Lehmann V., Becker K., Sch?ps R., Ulbrich-Hofmann R., Eder K.. Peptides and hydrolysates from casein and soy protein modulate the release of vasoactive substances from human aortic endothelial cells. Biochim. Biophys. Acta Gen. Subj., 1721, 89-97, 2005.
RECORD: Rec_0366906 VERIFIED: YES
Provenance & Taxonomy
Amaranthus hypochondriacus [Plant]
28502
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Enzyme inhibitory
PaperBioactive peptides in amaranth (Amaranthus hypochondriacus) seed PMID18211015 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18211015/