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MYP_066127
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Basic Information
Dermaseptin-S1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross
Reproductive biology ▸ Contraceptive activity ▸ Spermicidal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
34 amino acids
C152H257N43O44S2
Standard
Sequence
ALWKTMLKKLGTMALHAGKAALGAAADTISQGTQ
Physicochemical Analysis
3455.06 Da
10.00
2.88
2.63
0.0847
0.19
0.51
0.18
1.85
92.35
0.0294
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1396.80
-14.41
49.0
50.0
118.0
241.0
3.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0071464 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagii [Animal]
Dermaseptin
8395
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Antiparasitic Spermicidal
T. metagrophytes IP877-71
20 μM
MIC
PaperIsolation, amino acid sequence, and synthesis of dermaseptin, a novel antimicrobial peptide of amphibian skin
RECORD: Rec_0077553 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagei [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiprotozoal
Nocardia brasiliensis (IP 16-80)
200 μg/mL
MIC
PMID1909573;8306981 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1909573/
RECORD: Rec_0077796 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagii [Animal]
Dermaseptin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Bio-Activity Profile
Antimicrobial Antifungal
PaperA. Mor and P. Nicolas / European Journal of Biochemistry 219 (1994) 145-154. Isolation and structure of novel defensive peptides from frog skin Evidence URLhttps://www.uniprot.org/uniprotkb/P24302/entry
RECORD: Rec_0077850 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagii [Animal]
Dermaseptin
8395
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiparasitic Antileishmanial
Leishmania panamensis (promastigote)
63.8 μg/mL
EC50; Microscopy (Electron)
PaperAntiparasitic peptides PMID23615879 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23615879/
RECORD: Rec_0090474 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagii [Animal]
Dermaseptin
8395
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiparasitic Antileishmanial
Leishmania mexicana (promastigote)
3 μM
IC50; Microscopy (Electron)
PaperAntiparasitic peptides PMID23615879 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23615879/
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