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MYP_066127
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Basic Information
Dermaseptin-S1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross
Reproductive biology ▸ Contraceptive activity ▸ Spermicidal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
34 amino acids
C152H257N43O44S2
Standard
Sequence
ALWKTMLKKLGTMALHAGKAALGAAADTISQGTQ
Physicochemical Analysis
3455.06 Da
10.00
2.88
2.63
0.0847
0.19
0.51
0.18
1.85
92.35
0.0294
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1396.80
-14.41
49.0
50.0
118.0
241.0
3.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0053016 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagei [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiprotozoal
Aspergillus fumigatus (IP 1025-70)
100 μg/mL
MIC
PMID1909573;8306981 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1909573/
RECORD: Rec_0053423 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagii [Animal]
Dermaseptin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
1.0 μM
MIC
PaperA. Mor et al. / JBC 269 (1994) 31635-31641. The vertebrate peptide antibiotics dermaseptins have overlapping structural features but target specific microorganisms Evidence URLhttps://www.uniprot.org/uniprotkb/P24302/entry
RECORD: Rec_0053565 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagii [Animal]
Dermaseptin
8395
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Antiparasitic Spermicidal
Cryptococcus neoformans IP960-67 and IP962-67
0.5-1 μM
MIC
PaperIsolation, amino acid sequence, and synthesis of dermaseptin, a novel antimicrobial peptide of amphibian skin
RECORD: Rec_0055380 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Antibacterial Antiviral Antiparasitic Toxic Antimicrobial Antifungal Hemolytic Anti-Gram-positive Cytotoxic Antileishmanial Anti-Gram-negative
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
RECORD: Rec_0067826 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagii [Animal]
Dermaseptin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Bio-Activity Profile
Hemolytic Cytolytic
Erythrocytes
70.0 μM
HC50
PaperA. Mor et al. / JBC 269 (1994) 31635-31641. The vertebrate peptide antibiotics dermaseptins have overlapping structural features but target specific microorganisms Evidence URLhttps://www.uniprot.org/uniprotkb/P24302/entry
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