Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length456 amino acids

Chemical FormulaC2272H3569N565O657S17

DescriptionStandard

        MLPSMTVLLTLVSLTCGENPAIQVILKNKGLQYGKEVGAGWIQEKLELITLPDISGVIKLGFLGKVYYTLTGITITKCDFPEPTVEFYQDATGFKTSSLGLSVHGCDLYVNLGKDPDGRLSVTSISCDARVGEVDIRFHGGASHYFPFVDHFKGRIKSDIEGKICPTVEESILNVESHLQAMNVSFDVNQDLTIDLPLTGLPVIDASSLNLGLKGEFYSIKSPAEPPFEAQAFTIPEQQGYMLSMGLSEFTLNSASYGYFSAGLLKALINDSMIPPSSPVRLNTSSIGQFIPQLPKMFPDLLMSLQVYAREIPLFSFLPGAVKLGFQGAVKAFAIQANKTQTPLFKLNVDTQLSGKVWIASGKLKGSLKMDNFTLTLAASEVGPFKVQYTNQSYFKRSWTTICVFTNFKKSNILGKGVEIPRMRQAQLVNTVLQMEEGFIAIFSDAQVLLTLGGFN
    

Molecular Weight49856.14 Da

Isoelectric Point (pI)6.26

Net Charge (pH 7.0)-2.08

Net Charge (pH 7.4) -2.75

Charge Density (pH 7.0) -0.0046

GRAVY Index0.12

Hydrophobic Moment 0.62

Boman Index0.17

Instability Index31.80

Aliphatic Index 97.04

Aromaticity 0.0987

Extinction Coeff. Reduced 35870.00

Extinction Coeff. Oxidized 36245.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0087881 VERIFIED: NO

Provenance & Taxonomy

OrganismLabrus bergylta [Bacterium]

FamilyBPI

Tax ID56723

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence