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MYP_066098
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Basic Information
Unnamed
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
30 amino acids
C130H211N35O41S6
Standard
Sequence
GIPCGESCVFIPCISSVIGCSCSSKVCYRN
Physicochemical Analysis
3112.67 Da
7.77
0.70
0.41
0.0234
0.75
0.37
0.23
31.50
81.00
0.0667
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1199.56
-15.63
48.0
48.0
97.0
212.0
4.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0042172 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
RECORD: Rec_0060836 VERIFIED: YES
Provenance & Taxonomy
Viola philippica [Plant]
Cyclotide
39648
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
Human cervical carcinoma HeLa
5.24±0.40 μM
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola philippica PMID21723349 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21723349/
RECORD: Rec_0081126 VERIFIED: NO
Provenance & Taxonomy
Viola philippica [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
disulfide-stabilized; exact pairings not extracted
cystine-knot scaffold
Bio-Activity Profile
Anticancer Antimicrobial
PaperPlant Antimicrobial Oligopeptides with Anticancer Properties as a Source of Biologically Active Peptides—An In Silico Study PMID41009751 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/41009751/
RECORD: Rec_0121232 VERIFIED: YES
Provenance & Taxonomy
Viola philippica [Plant]
Cyclotide
39648
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
Human gastric cancer BGC-823
PaperIsolation and characterization of cytotoxic cyclotides from Viola philippica PMID21723349 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21723349/
RECORD: Rec_0133961 VERIFIED: YES
Provenance & Taxonomy
Viola philippica [Plant]; Insecta [Animal]
33090; 50557
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID21723349 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21723349/
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