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MYP_065984
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Basic Information
DV2(419-447)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-Dengue virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Standard
29 amino acids
C139H202N34O37
Standard
Sequence
AWDFGSLGGVFTSIGKALHQVFGAIYGAA
Physicochemical Analysis
2941.30 Da
6.79
-0.12
-0.36
-0.0041
0.74
0.61
0.47
-3.00
91.03
0.1724
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1109.92
-9.04
39.0
38.0
91.0
210.0
7.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0251572 VERIFIED: YES
Provenance & Taxonomy
Dengue virus 2 [Virus]
Virus-derived peptide
11060;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Dengue 2 virus (Virus entry); BHK-21
0.3 μM
IC90
PaperPeptide inhibitors of flavivirus entry derived from the E protein stem. | Schmidt AG, Yang PL, Harrison SC. | J Virol. 2010 | PMID:20881042 PMID20881042 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20881042/
RECORD: Rec_0254978 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-DENV Infection inhibition
DENV2 (dengue virus type 2) | BHK-21 cells
250 μM
IC90
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperPeptide inhibitors of flavivirus entry derived from the E protein stem. | Schmidt AG, Yang PL, Harrison SC. | J Virol. 2010 Dec;84(24):12549-54. | DOI:10.1128/JVI.01440-10 | PMID:20881042 PMID20881042 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20881042/
RECORD: Rec_0348845 VERIFIED: YES
Provenance & Taxonomy
Dengue virus 3 [Virus]
Virus-derived peptide
11069;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Dengue 3 virus (Virus entry); BHK-21
2 μM
IC90
PaperPeptide inhibitors of flavivirus entry derived from the E protein stem. | Schmidt AG, Yang PL, Harrison SC. | J Virol. 2010 | PMID:20881042 PMID20881042 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20881042/
RECORD: Rec_0359919 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 55.2%, E 0.0%, T 27.6%, C 17.2% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0399466 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
DENV-1
0.1 μM
IC90
PMID20881042 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20881042/
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