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MYP_065984
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Basic Information
DV2(419-447)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-Dengue virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Standard
29 amino acids
C139H202N34O37
Standard
Sequence
AWDFGSLGGVFTSIGKALHQVFGAIYGAA
Physicochemical Analysis
2941.30 Da
6.79
-0.12
-0.36
-0.0041
0.74
0.61
0.47
-3.00
91.03
0.1724
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1109.92
-9.04
39.0
38.0
91.0
210.0
7.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0057472 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-DENV Entry inhibition
Dengue 1 virus (DENV1) | BHK-21 cells
0.1 μM
IC90
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperPeptide inhibitors of flavivirus entry derived from the E protein stem. | Schmidt AG, Yang PL, Harrison SC. | J Virol. 2010 Dec;84(24):12549-54. | DOI:10.1128/JVI.01440-10 | PMID:20881042 PMID20881042 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20881042/
RECORD: Rec_0061664 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-DENV Entry inhibition
Dengue 4 virus (DENV4) | BHK-21 cells
0.7 μM
IC90
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperPeptide inhibitors of flavivirus entry derived from the E protein stem. | Schmidt AG, Yang PL, Harrison SC. | J Virol. 2010 Dec;84(24):12549-54. | DOI:10.1128/JVI.01440-10 | PMID:20881042 PMID20881042 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20881042/
RECORD: Rec_0072551 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
DENV-3
2 μM
IC90
PMID20881042 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20881042/
RECORD: Rec_0134286 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 20881042 PMID20881042 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20881042/
RECORD: Rec_0160736 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Dengue 4 virus(DENV4):inhibition of infection in BHK-21 cells
0.7 μM
IC90
PaperPubMed PMID: 20881042 PMID20881042 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20881042/
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