Peptide Database

Peptide NameBeta-defensin 135

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length78 amino acids

Chemical FormulaC404H646N102O100S6

DescriptionStandard

        MATRSVLLALVVLNLLFYVPPGRSGPNVYIQKIFASCWRLQGTCRPKCLKNETISYFGVILYICGCVNPKYLPILTGK
    

Molecular Weight8724.46 Da

Isoelectric Point (pI)9.62

Net Charge (pH 7.0)7.44

Net Charge (pH 7.4) 7.14

Charge Density (pH 7.0) 0.0954

GRAVY Index0.50

Hydrophobic Moment 0.66

Boman Index0.21

Instability Index47.83

Aliphatic Index 114.87

Aromaticity 0.1154

Extinction Coeff. Reduced 12950.00

Extinction Coeff. Oxidized 13200.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3203.60

LogP -21.33

H-bond Donors 116.0

H-bond Acceptors 114.0

Rotatable Bonds 277.0

Heavy Atoms 612.0

Ring Count 16.0

Amide Bonds 83.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0003101 VERIFIED: NO

Provenance & Taxonomy

OrganismPan troglodytes [Animal]

FamilyDefensin

Tax ID9598

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Defensin Non-hemolytic Non-ribosomal

MethodQualitative functional evidence

PaperCross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract PMID16033865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16033865/; https://www.uniprot.org/uniprotkb/Q30KJ4/entry; https://bblserver.org.in/ampdb/