Peptide Database

Peptide NameSLAY-screened peptide P5068

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC107H167N33O30

DescriptionStandard

        PRRVFPHLQDNQDYAKNAIL
    

Molecular Weight2395.67 Da

Isoelectric Point (pI)9.00

Net Charge (pH 7.0)1.05

Net Charge (pH 7.4) 0.93

Charge Density (pH 7.0) 0.0523

GRAVY Index-0.94

Hydrophobic Moment 0.58

Boman Index-0.23

Instability Index97.26

Aliphatic Index 83.00

Aromaticity 0.1000

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1039.13

LogP -9.58

H-bond Donors 35.0

H-bond Acceptors 32.0

Rotatable Bonds 77.0

Heavy Atoms 170.0

Ring Count 5.0

Amide Bonds 23.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0406461 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/