Peptide Database

Peptide NameBeta-defensin 126

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length108 amino acids

Chemical FormulaC513H842N142O147S13

DescriptionStandard

        MKSLLFTLAVFMLLAQLVSGNWYVKKCLNDVGICKKKCKPGEMHIKNGWATCGKQRDCCVPADRRANYPAFCVQTKTTRTSTVTAKTTLMVTTASMSSMAPTPVSPTG
    

Molecular Weight11767.88 Da

Isoelectric Point (pI)9.68

Net Charge (pH 7.0)10.51

Net Charge (pH 7.4) 10.12

Charge Density (pH 7.0) 0.0973

GRAVY Index-0.03

Hydrophobic Moment 0.46

Boman Index0.03

Instability Index36.24

Aliphatic Index 68.61

Aromaticity 0.0648

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 14355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4634.48

LogP -50.96

H-bond Donors 170.0

H-bond Acceptors 172.0

Rotatable Bonds 386.0

Heavy Atoms 815.0

Ring Count 16.0

Amide Bonds 114.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0087557 VERIFIED: NO

Provenance & Taxonomy

OrganismPan troglodytes [Animal]

FamilyDefensin

Tax ID9598

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Defensin Non-hemolytic Non-ribosomal

MethodQualitative functional evidence

PaperCross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract PMID16033865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16033865/; https://www.uniprot.org/uniprotkb/Q30KK2/entry; https://bblserver.org.in/ampdb/