Peptide Database

Peptide NameLepirudin

Function Ontology

Hemostasis ▸ Anticoagulant activity

Therapeutic / Biomedical activity ▸ Enzyme replacement therapy

Standard StatusStandard

Sequence Length65 amino acids

Chemical FormulaC287H446N80O111S6

DescriptionStandard

        LTYTDCTESGQNLCLCEGSNVCGQGNKCILGSDGEKNQCVTGEGTPKPQSHNDGDFEEIPEEYLQ
    

Molecular Weight6985.47 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-9.19

Net Charge (pH 7.4) -9.55

Charge Density (pH 7.0) -0.1414

GRAVY Index-0.85

Hydrophobic Moment 0.47

Boman Index-0.08

Instability Index49.31

Aliphatic Index 50.92

Aromaticity 0.0462

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3107.12

LogP -43.27

H-bond Donors 106.0

H-bond Acceptors 109.0

Rotatable Bonds 234.0

Heavy Atoms 484.0

Ring Count 7.0

Amide Bonds 74.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0006093 VERIFIED: NO

Provenance & Taxonomy

OrganismSaccharomyces cerevisiae [Fungus]

FamilyEnzyme

Tax ID4932

Structure & Mods

Configsingle-chain therapeutic peptide/protein [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Enzyme replacement Anticoagulant

Half-LifeApproximately 1.3 hours

RECORD: Rec_0297994 VERIFIED: NO