Peptide Database

Peptide NameSLAY-screened peptide P2438

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC124H169N33O26S

DescriptionStandard

        LRQTPPHFYFNLCYPHWRPP
    

Molecular Weight2569.94 Da

Isoelectric Point (pI)9.31

Net Charge (pH 7.0)1.92

Net Charge (pH 7.4) 1.60

Charge Density (pH 7.0) 0.0961

GRAVY Index-0.94

Hydrophobic Moment 0.36

Boman Index-0.04

Instability Index73.50

Aliphatic Index 39.00

Aromaticity 0.2500

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 916.09

LogP -3.75

H-bond Donors 31.0

H-bond Acceptors 31.0

Rotatable Bonds 67.0

Heavy Atoms 184.0

Ring Count 13.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0414879 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/