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MYP_065618
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Basic Information
Ac-SAHS-NH2
Antimicrobial
Antiviral
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-H1N1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Standard
4 amino acids
C15H24N6O7
Standard
Sequence
SAHS
Physicochemical Analysis
400.39 Da
6.46
-0.45
-0.71
-0.1132
-0.75
0.23
-0.04
-13.72
25.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
219.76
-4.18
8.0
8.0
11.0
28.0
1.0
3.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0004561 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferrin-derived peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acylation
Amidation
Acylation
Bio-Activity Profile
Antiviral Anti-H1N1 Replication inhibition
A/Parma/24/09 H1N1 | MDCK cells
0.00000000043±0.00000000003 μM
EC50
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperDiscovery of a Novel Tetrapeptide against Influenza A Virus: Rational Design, Synthesis, Bioactivity Evaluation and Computational Studies. | Scala MC, Agamennone M, Pietrantoni A, Di Sarno V, Bertamino A, Superti F, Campiglia P, Sala M. | Pharmaceuticals (Basel). 2021 Sep 23;14(10):959. | DOI:10.3390/ph14100959 | PMID:34681184 PMID34681184 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34681184/
RECORD: Rec_0054774 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
Virus:A/Roma-ISS/02/08 H1N1:inhibition of virus replication in MDCK cells
5.77±0.01 μM
EC50
PMID34681184 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34681184/
RECORD: Rec_0192815 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferrin-derived peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acylation
Amidation
Acylation
Bio-Activity Profile
Antiviral Anti-H3N2 Replication inhibition
A/Parma0/5/06 H3N2 | MDCK cells
0.000000936±0.00000001 μM
EC50
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperDiscovery of a Novel Tetrapeptide against Influenza A Virus: Rational Design, Synthesis, Bioactivity Evaluation and Computational Studies. | Scala MC, Agamennone M, Pietrantoni A, Di Sarno V, Bertamino A, Superti F, Campiglia P, Sala M. | Pharmaceuticals (Basel). 2021 Sep 23;14(10):959. | DOI:10.3390/ph14100959 | PMID:34681184 PMID34681184 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34681184/
RECORD: Rec_0205458 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferrin-derived peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acylation
Amidation
Acylation
Bio-Activity Profile
Antiviral Anti-H1N1 Replication inhibition
A/Roma-ISS/02/08 H1N1 | MDCK cells
0.000000577±0.000000001 μM
EC50
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperDiscovery of a Novel Tetrapeptide against Influenza A Virus: Rational Design, Synthesis, Bioactivity Evaluation and Computational Studies. | Scala MC, Agamennone M, Pietrantoni A, Di Sarno V, Bertamino A, Superti F, Campiglia P, Sala M. | Pharmaceuticals (Basel). 2021 Sep 23;14(10):959. | DOI:10.3390/ph14100959 | PMID:34681184 PMID34681184 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34681184/
RECORD: Rec_0298972 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Ac
Amidation
Bio-Activity Profile
Antiviral
A/Parma/24/09 H1N1
PMID34681184 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34681184/
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