Peptide Database

Peptide NamePotassium channel toxin alpha-KTx 2.17

Function Ontology

Membrane / Ion-channel modulation ▸ Ion channel modulation

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length39 amino acids

Chemical FormulaC180H303N53O49S7

DescriptionStandard

        TIINVKCTSPKQCLLPCKQIYGPHAGAKCMNGKCHCSKI
    

Molecular Weight4218.11 Da

Isoelectric Point (pI)9.27

Net Charge (pH 7.0)5.51

Net Charge (pH 7.4) 5.12

Charge Density (pH 7.0) 0.1412

GRAVY Index-0.10

Hydrophobic Moment 0.36

Boman Index0.02

Instability Index50.92

Aliphatic Index 72.56

Aromaticity 0.0256

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1629.74

LogP -17.78

H-bond Donors 60.0

H-bond Acceptors 64.0

Rotatable Bonds 140.0

Heavy Atoms 289.0

Ring Count 6.0

Amide Bonds 42.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0100325 VERIFIED: YES

Provenance & Taxonomy

OrganismCentruroides tecomanus [Animal]

Structure & Mods

Configdisulfide-stabilized linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide7-29; 13-34; 17-36

Bio-Activity Profile

Function

Toxin Ion channel blocker Potassium channel blocker

TargetKv1.1/KCNA1

Activity0.0048 μM

MethodIC50

RECORD: Rec_0218233 VERIFIED: YES