Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length81 amino acids

Chemical FormulaC422H664N100O119S5

DescriptionStandard

        MEVEKILVLCGCFLLWNPLIQSTQVYPGIKLRITQKGLDYGMQAGMEAIEPIVKKNGIPDFKGSESLEFLKVDYVDYNFSK
    

Molecular Weight9202.71 Da

Isoelectric Point (pI)5.28

Net Charge (pH 7.0)-1.51

Net Charge (pH 7.4) -1.79

Charge Density (pH 7.0) -0.0186

GRAVY Index0.02

Hydrophobic Moment 0.61

Boman Index0.13

Instability Index10.20

Aliphatic Index 100.99

Aromaticity 0.1111

Extinction Coeff. Reduced 11460.00

Extinction Coeff. Oxidized 11585.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3518.94

LogP -23.25

H-bond Donors 119.0

H-bond Acceptors 123.0

Rotatable Bonds 310.0

Heavy Atoms 646.0

Ring Count 14.0

Amide Bonds 87.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0295425 VERIFIED: NO

Provenance & Taxonomy

OrganismVombatus ursinus [Bacterium]

FamilyBPI

Tax ID29139

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence