Peptide Database

Peptide NameMaximins 1 H1 [Cleaved into: Maximin-1 (Host defense peptide) (HDP); Maximin-H1 (Maximin-6)]

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Antiviral

Antiviral ▸ Anti-HIV

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide

Reproductive biology ▸ Contraceptive activity ▸ Spermicidal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length144 amino acids

Chemical FormulaC700H1150N196O223S3

DescriptionStandard

        MNFKYIVAVSFLLASAYARSEENDEQSLSQRDVLEEESLREIRGIGTKILGGVKTALKGALKELASTYANGKRTAEEHEVMKRLEAVMRDLDSLDYPEEAAERETRSFNQEEIANLFTKKEKRILGPVISTIGGVLGGLLKNLG
    

Molecular Weight15975.99 Da

Isoelectric Point (pI)5.38

Net Charge (pH 7.0)-3.37

Net Charge (pH 7.4) -3.69

Charge Density (pH 7.0) -0.0234

GRAVY Index-0.38

Hydrophobic Moment 0.71

Boman Index-0.07

Instability Index52.05

Aliphatic Index 95.56

Aromaticity 0.0556

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 5960.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 6848.78

LogP -68.50

H-bond Donors 239.0

H-bond Acceptors 224.0

Rotatable Bonds 561.0

Heavy Atoms 1122.0

Ring Count 11.0

Amide Bonds 152.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0393417 VERIFIED: YES

Provenance & Taxonomy

OrganismBombina maxima [Animal]

FamilyBombinin; Maximin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Antiviral Anti-HIV Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Toxin Cytotoxic Hemolytic Spermicidal

TargetGram Negative Bacteria and Gram Positive Bacteria