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MYP_065365
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Basic Information
p2(gag) peptide[M4A]
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Enzyme modulation ▸ Enzyme inhibition ▸ Maturation inhibitor
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Standard
14 amino acids
C57H98N16O23S
Standard
Sequence
AEAASQVTNTATIM
Physicochemical Analysis
1407.55 Da
4.05
-1.20
-1.39
-0.0858
0.31
0.41
0.21
-5.21
77.14
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
646.02
-9.62
22.0
23.0
45.0
97.0
0.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0051468 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV:inhibition of protease activity in CEM/LAV-1 cells
142 μM
IC50
PMID15113844 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15113844/
RECORD: Rec_0132616 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Maturation inhibitor Protease inhibition
CEM/LAV-1
142 μM
IC50
PaperBlocking of human immunodeficiency virus type-1 virion autolysis by autologous p2(gag) peptide. PMID15113844 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15113844/
RECORD: Rec_0175027 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV
HIV | CEM/LAV-1 cells
142 μM
IC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperBlocking of human immunodeficiency virus type-1 virion autolysis by autologous p2(gag) peptide. | Misumi S, Morikawa Y, Tomonaga M, Ohkuma K, Takamune N, Shoji S. | J Biochem. 2004 Mar;135(3):447-53. | DOI:10.1093/jb/mvh052 | PMID:15113844 PMID15113844 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15113844/
RECORD: Rec_0255111 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PMID15113844 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15113844/
RECORD: Rec_0335566 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 50.0%, T 35.7%, C 14.3% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperHIPdb: a database of experimentally validated HIV inhibiting peptides PMID23359817 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23359817/
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