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MYP_065348
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Basic Information
Unnamed
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
29 amino acids
C116H185N35O40S6
Standard
Sequence
GLPICGETCVGGSCNTPGCSCSWPVCTRN
Physicochemical Analysis
2902.31 Da
5.96
-0.30
-0.59
-0.0102
0.16
0.26
0.15
54.12
46.90
0.0345
5500.00
5875.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1174.30
-18.65
46.0
46.0
85.0
197.0
5.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0048989 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
RECORD: Rec_0074839 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]; Viola tricolor [Plant]
Cyclotide
214053
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Anticancer Cytotoxic Antimicrobial Enzymatic-degradation
Human glioblastoma U251-MG
46.62 μg/mL
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola tricolor | PubMed PMID 10075760 PMID10075760;20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10075760/
RECORD: Rec_0088610 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Anticancer
PaperPubMed PMID: 10075760 PMID10075760 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10075760/
RECORD: Rec_0103164 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
PaperSeven novel macrocyclic polypeptides from Viola arvensis.
RECORD: Rec_0118027 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]
Cyclotide
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
5-19; 9-21; 14-26
Three disulfide bonds
Bio-Activity Profile
Anticancer
Mammalian 30 h; Yeast >20 h; E. coli >10 h
PaperSeven novel macrocyclic polypeptides from Viola arvensis PMID10075760 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10075760/
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