Peptide Database

Peptide NameSLAY-screened peptide P2916

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC91H140N28O33S3

DescriptionStandard

        LTSHCQDADCHDMHEPAINI
    

Molecular Weight2250.45 Da

Isoelectric Point (pI)4.62

Net Charge (pH 7.0)-3.99

Net Charge (pH 7.4) -4.38

Charge Density (pH 7.0) -0.1996

GRAVY Index-0.52

Hydrophobic Moment 0.36

Boman Index-0.01

Instability Index97.28

Aliphatic Index 68.50

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 969.31

LogP -11.39

H-bond Donors 33.0

H-bond Acceptors 35.0

Rotatable Bonds 71.0

Heavy Atoms 155.0

Ring Count 4.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0146700 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/