Peptide Database

Peptide Name2-

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Influenza virus

Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC92H168N26O19

DescriptionStandard

        RRKKVALLPAVLLALLAP
    

Molecular Weight1942.48 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)3.76

Net Charge (pH 7.4) 3.55

Charge Density (pH 7.0) 0.2088

GRAVY Index1.02

Hydrophobic Moment 0.26

Boman Index0.18

Instability Index68.65

Aliphatic Index 184.44

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 716.28

LogP -1.90

H-bond Donors 25.0

H-bond Acceptors 23.0

Rotatable Bonds 63.0

Heavy Atoms 137.0

Ring Count 2.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0386072 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-Influenza virus Replication inhibition

TargetInfluenza virus | MDCK cells

Activity10 μM

Method% inhibition

Half-LifeMammalian: 1 h; Yeast: 2 min; E. coli: 2 min

PaperIdentification of the minimal active sequence of an anti-influenza virus peptide. | Jones JC, Settles EW, Brandt CR, Schultz-Cherry S. | Antimicrob Agents Chemother. 2011 Apr;55(4):1810-3. | DOI:10.1128/AAC.01428-10 | PMID:21220525 PMID21220525 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21220525/

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