Peptide Database

Peptide Namedes-His1-[Leu4-Glu9]glucagon-NH2

Function Ontology

Hormonal / Endocrine ▸ Hormonal activity

Metabolic ▸ Glucose metabolism ▸ Antidiabetic

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Receptor modulation ▸ Antagonist

Standard StatusStandard

Sequence Length28 amino acids

Chemical FormulaC152H228N40O48S

DescriptionStandard

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Molecular Weight3415.74 Da

Isoelectric Point (pI)5.84

Net Charge (pH 7.0)-0.54

Net Charge (pH 7.4) -0.75

Charge Density (pH 7.0) -0.0192

GRAVY Index-0.76

Hydrophobic Moment 0.66

Boman Index-0.15

Instability Index67.58

Aliphatic Index 55.71

Aromaticity 0.1786

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1480.96

LogP -15.59

H-bond Donors 53.0

H-bond Acceptors 49.0

Rotatable Bonds 112.0

Heavy Atoms 241.0

Ring Count 6.0

Amide Bonds 31.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0128118 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyGtoPdb peptide ligand

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Receptor antagonist Antidiabetic Hormonal activity

Targetglucagon receptor (Rat)