Peptide Database

Peptide NameSLAY-screened peptide P2942

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC117H148N26O30

DescriptionStandard

        GRDLYPAGSYGAFFWDYHYL
    

Molecular Weight2398.58 Da

Isoelectric Point (pI)5.21

Net Charge (pH 7.0)-1.15

Net Charge (pH 7.4) -1.42

Charge Density (pH 7.0) -0.0577

GRAVY Index-0.38

Hydrophobic Moment 0.44

Boman Index0.21

Instability Index44.95

Aliphatic Index 49.00

Aromaticity 0.3500

Extinction Coeff. Reduced 11460.00

Extinction Coeff. Oxidized 11460.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 889.55

LogP -3.68

H-bond Donors 32.0

H-bond Acceptors 30.0

Rotatable Bonds 67.0

Heavy Atoms 173.0

Ring Count 10.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0150247 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/