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MYP_065179
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Basic Information
Beta-defensin 103 (Beta-defensin 3) (BD-3) (DEFB-3) (HBD3) (hBD-3) (Defensin; beta 103) (Defensin-like protein)
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
67 amino acids
C344H568N104O82S7
Standard
Sequence
MRIHYLLFALLFLFLVPVPGHGGIINTLQKYYCRVRGGRCAVLSCLPKEEQIGKCSTRGRKCCRRKK
Physicochemical Analysis
7697.29 Da
10.15
11.61
11.19
0.1733
0.00
0.63
-0.05
55.16
95.97
0.0896
4470.00
4845.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
3011.71
-23.80
115.0
103.0
259.0
537.0
11.0
69.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0229345 VERIFIED: NO
Provenance & Taxonomy
Macaca mulatta [Animal]
9544
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiotic Antimicrobial Defensin Non-hemolytic Non-ribosomal
Qualitative functional evidence
PMID17431167 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17431167/; https://www.uniprot.org/uniprotkb/F6SW26/entry; https://bblserver.org.in/ampdb/
RECORD: Rec_0266548 VERIFIED: YES
Provenance & Taxonomy
Macaca fascicularis [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Defensin Non-hemolytic Non-ribosomal
PMID22002653 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22002653/
RECORD: Rec_0350319 VERIFIED: NO
Provenance & Taxonomy
Mandrillus leucophaeus [Animal]
Defensin
9568
Structure & Mods
linear polypeptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiotic Antimicrobial Defensin Non-hemolytic
Qualitative functional evidence
Evidence URLhttps://www.uniprot.org/uniprotkb/A0A2K5Z5Q1/entry
RECORD: Rec_0369483 VERIFIED: NO
Provenance & Taxonomy
Pongo pygmaeus [Animal]
Defensin
9600
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiotic Antimicrobial Defensin Anti-Gram-negative Anti-Gram-positive Non-hemolytic Non-ribosomal
Gram-negative bacteria; Gram-positive bacteria
Qualitative functional evidence
Evidence URLhttps://www.uniprot.org/uniprotkb/A4H200/entry; https://bblserver.org.in/ampdb/
RECORD: Rec_0420178 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Beta-defensin; Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Defensin Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Hemolytic
Staphylococcus aureus (Gram-positive)
PMID11085990;11702237;11223260;11741980 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11085990/
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