Peptide Database

Peptide NameSLAY-screened peptide P2083

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC71H101N17O15S

DescriptionStandard

        TLPWQLPCLHWA
    

Molecular Weight1464.73 Da

Isoelectric Point (pI)6.40

Net Charge (pH 7.0)-0.52

Net Charge (pH 7.4) -0.78

Charge Density (pH 7.0) -0.0437

GRAVY Index0.28

Hydrophobic Moment 0.06

Boman Index0.39

Instability Index33.71

Aliphatic Index 105.83

Aromaticity 0.1667

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 489.42

LogP -0.11

H-bond Donors 17.0

H-bond Acceptors 17.0

Rotatable Bonds 38.0

Heavy Atoms 104.0

Ring Count 7.0

Amide Bonds 12.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0216200 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/