Peptide Database

Peptide NameSLAY-screened peptide P2963

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC120H171N31O28S

DescriptionStandard

        DCRHPTNNVPFKYFRPLFLY
    

Molecular Weight2527.90 Da

Isoelectric Point (pI)9.20

Net Charge (pH 7.0)1.84

Net Charge (pH 7.4) 1.56

Charge Density (pH 7.0) 0.0918

GRAVY Index-0.60

Hydrophobic Moment 0.54

Boman Index-0.08

Instability Index31.55

Aliphatic Index 53.50

Aromaticity 0.2500

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 952.52

LogP -5.34

H-bond Donors 33.0

H-bond Acceptors 32.0

Rotatable Bonds 73.0

Heavy Atoms 180.0

Ring Count 9.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0140327 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/