Peptide Database

Peptide NameSLAY-screened peptide P1490

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC106H166N22O35

DescriptionStandard

        LVDVEFTWLNVSESIILETT
    

Molecular Weight2308.58 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-4.23

Net Charge (pH 7.4) -4.44

Charge Density (pH 7.0) -0.2115

GRAVY Index0.69

Hydrophobic Moment 0.29

Boman Index0.34

Instability Index29.53

Aliphatic Index 141.00

Aromaticity 0.1000

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 925.45

LogP -6.15

H-bond Donors 32.0

H-bond Acceptors 31.0

Rotatable Bonds 74.0

Heavy Atoms 163.0

Ring Count 3.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0379851 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/