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MYP_064957
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Basic Information
E1P40-1
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Standard
18 amino acids
C107H150N26O31S
Standard
Sequence
CELKWESEFWRWTEQLAS
Physicochemical Analysis
2328.56 Da
4.49
-2.24
-2.47
-0.1244
-0.90
0.60
-0.09
71.00
48.89
0.2222
16500.00
16500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
946.29
-5.42
35.0
30.0
74.0
165.0
7.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0106614 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Virus:HIV-1 NL4-3:inhibition of virus infection in TZM-bl cells
34±15.4 μM
IC50
PMID26905802 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26905802/
RECORD: Rec_0224921 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 NL4-3 | TZM-bl cells
34±15.4 μM
IC50
Mammalian: 1.2 h; Yeast: >20 h; E. coli: >10 h
PaperDefinition of an 18-mer Synthetic Peptide Derived from the GB virus C E1 Protein as a New HIV-1 Entry Inhibitor. | Gómara MJ, Sánchez-Merino V, Paús A, Merino-Mansilla A, Gatell JM, Yuste E, Haro I. | Biochim Biophys Acta. 2016 Jun;1860(6):1139-48. | DOI:10.1016/j.bbagen.2016.02.008 | PMID:26905802 PMID26905802 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26905802/
RECORD: Rec_0410684 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 NL4-3
34±15.4 μM
IC50
PMID26905802 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26905802/