Peptide Database

Peptide NameGalcanezumab

Function Ontology

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Therapeutic / Biomedical activity ▸ Enzyme replacement therapy

Standard StatusStandard

Sequence Length445 amino acids

Chemical FormulaC2168H3347N569O675S17

DescriptionStandard

        QVQLVQSGAEVKKPGSSVKVSCKASGYTFGNYWMQWVRQAPGQGLEWMGAIYEGTGKTVYIQKFADRVTITADKSTSTAYMELSSLRSEDTAVYYCARLSDYVSGFGYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG
    

Molecular Weight48727.28 Da

Isoelectric Point (pI)7.60

Net Charge (pH 7.0)1.30

Net Charge (pH 7.4) 0.45

Charge Density (pH 7.0) 0.0029

GRAVY Index-0.38

Hydrophobic Moment 0.63

Boman Index0.02

Instability Index42.90

Aliphatic Index 67.12

Aromaticity 0.0989

Extinction Coeff. Reduced 80790.00

Extinction Coeff. Oxidized 81415.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0160373 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyMonoclonal antibody

Tax ID9606

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Immunomodulatory Enzyme replacement

Half-LifeThe mean serum half-life of galcanezumab is similar at all dose levels at about 25-30 days.[A33112] The elimination half-life of galcanezumab was ultimately approximately 27 days.[L4894]