Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length450 amino acids

Chemical FormulaC2286H3579N569O651S23

DescriptionStandard

        MITGWMDGWMEQVLEMCTKMVQVLWGCFLLWNLYISSAQTIYPGIKARATQRALDYGIQAGMEMIEQMVKKRNIPDLKGSESLEFLKIDYVNYNFKNIKINAFSLPNTSLAFVPGVGIRALINHGTANISTDWEIKSPLFQDTGGADLFLSGVYFTGIVVLAWNDFGHPILKLQNCCARVSHSDVSFSGELSVLYNSFSEPMEKPILKNLNKMLCPIITSEVEALNANLSMLKALRKIDNYTLLDYSLISSPEITENYVDLNLKGVFYPLENLTDTPFSSVPFVLPEHSDSMIYIGISEYFFKSASYAYFTAGAFNVTLTTKEIFNHLIRNSQGLGSMLSQIAELYILSQPFMVKVLATEPPVVNLLPGNFTLDIPASFVIFTQSKNSTAKTIVSMDFVASTNVALAILGQRLICSLSLKRIKVWPSKREKLVPRHMTSQEGLKSCGVGP
    

Molecular Weight50186.79 Da

Isoelectric Point (pI)6.61

Net Charge (pH 7.0)-1.01

Net Charge (pH 7.4) -1.74

Charge Density (pH 7.0) -0.0022

GRAVY Index0.16

Hydrophobic Moment 0.69

Boman Index0.17

Instability Index35.31

Aliphatic Index 100.51

Aromaticity 0.1044

Extinction Coeff. Reduced 62340.00

Extinction Coeff. Oxidized 62715.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0135797 VERIFIED: NO

Provenance & Taxonomy

OrganismBalaenoptera musculus [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria