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MYP_064874
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Basic Information
Lactoferricin B
Anticancer
Anticancer ▸ Apoptosis induction
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Binding / Molecular interaction ▸ Binding activity
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
25 amino acids
C141H226N46O29S3
Standard
Sequence
FKCRRWQWRMKKLGAPSITCVRRAF
Physicochemical Analysis
3125.79 Da
11.84
7.74
7.50
0.3095
-0.58
0.57
-0.31
77.92
50.80
0.1600
11000.00
11125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1255.62
-9.15
50.0
40.0
103.0
219.0
7.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0205700 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferrin-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
DNA repair-promoting DNA synthesis-promoting Pro-apoptotic
Caco-2 cells
PaperReduction of ultraviolet light-induced DNA damage in human colon cancer cells treated with a lactoferrin-derived peptide | Freiburghaus, C. et al. | DOI: 10.3168/jds.2011-5279 Evidence URLhttps://www.uniprot.org/uniprotkb/P24627/entry
RECORD: Rec_0225931 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferricin
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
3-20
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Anticancer
S. mutans, C. diphtheriae, Listeria monocytogenes IDF-1 b
0.3 μM
MIC
PaperAntibacterial spectrum of lactoferricin B, a potent bactericidal peptide derived from the N-terminal region of bovine lactoferrin.
RECORD: Rec_0250329 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferricin
9913
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
3-20
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
MIC
PaperComparison of NMR structures and model-membrane interactions of 15-residue antimicrobial peptides derived from bovine lactoferricin | Weiguo, J. et al. | DOI: 10.1139/o06-052 Evidence URLhttps://www.uniprot.org/uniprotkb/P24627/entry
RECORD: Rec_0266339 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferrin-derived
9913;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
19-36
Bio-Activity Profile
Antibiofilm Antifungal
Aspergillus fumigatus
20.489 μM
XTT assay
RECORD: Rec_0284028 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferricin
9913.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
PaperGaldiero S., Falanga A., Tarallo R., Russo L., Galdiero E., Cantisani M., Morelli G., Galdiero M.. Peptide inhibitors against herpes simplex virus infections. J. Pept. Sci., 19, 148-158, 2013.
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